Hiroshi was ordered to collect the fruit of cactus and was transferred to Mexico. So, Nohara family had to move to Mexico and live there. They had to bid farewell to their acquaintances and the citizens of Kasukabe with tears. Shinnosuke heard that Mexican young girls are stylish and beautiful and became eager for this journey. On arriving at Madakueruyobaka city in Mexico, a new life full of anxiety, surrounded by unique neighbours awaits them. But Shinnosuke and Nohara family had no idea that flesh-eating killer cactuses are going to attack. Now it is up to Nohara family along with the neighbours of Mexico to overcome this trouble.